Home India Ministry of Finance Manufactured Drugs and Psychotropic Substances Notification...
Date: 2026-02-18 Category: Not Applicable State: Union Government Country: India

Manufactured Drugs and Psychotropic Substances Notification

Issued by Ministry of Finance · Department of Revenue

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Executive Summary & Key Takeaways

**Executive Summary** The document is a notification from the Ministry of Finance, Department of Revenue, Government of India, dated February 18, 2026. It declares specified substances, salts, and preparations thereof as manufactured drugs under the Narcotic Drugs and Psychotropic Substances Act, 1985 and includes additional amendments in the list of psychotropic substances specified in the Schedule to the said Act. The notification comes into force from the date of its publication in the Official Gazette. **Key Points / Main Content** * **Declaration of Manufactured Drugs (S.O. 905(E)):** The following substances, salts, and preparations are declared manufactured drugs: * N-Pyrrolidino protonitazene * N-Pyrrolidino metonitazene * Etonitazepipne (N-piperidinyl etonitazene) * N-Desethyl-isotonitazene (norisotonitazene) * **Amendments to Psychotropic Substances List (S.O. 906(E)):** The following substances are added to the list of psychotropic substances in the Schedule to the Narcotic Drugs and Psychotropic Substances Act, 1985: * Hexahydrocannabinol (HHC) * Carisoprodol * **Small and Commercial Quantities (S.O. 907(E)):** The following substances are added to the list of small and commercial quantities of narcotic drug and psychotropic substance: * N-Pyrrolidino protonitazene * N-Pyrrolidino metonitazene * Etonitazepipne (N-piperidinyl etonitazene) * N-Desethyl-isotonitazene (norisotonitazene) * Hexahydrocannabinol (HHC) * Carisoprodol * **Effective Date:** All notifications come into force from the date of their publication in the Official Gazette. **Impact Analysis** **Stakeholder:** Central Government (Ministry of Finance, Department of Revenue) * **Impact:** The notification clarifies the classification and control of certain substances under the Narcotic Drugs and Psychotropic Substances Act, 1985. * **Action Required:** Enforce the regulations outlined in the notification. **Stakeholder:** Law Enforcement Agencies * **Impact:** The notification provides updated guidelines for identifying, regulating, and prosecuting offenses related to the newly listed manufactured drugs and psychotropic substances. * **Action Required:** Update drug identification and enforcement protocols to include the newly listed substances. **Stakeholder:** Pharmaceutical Manufacturers and Distributors * **Impact:** The notification affects the manufacturing, distribution, and sale of the listed substances. * **Action Required:** Ensure compliance with the regulations outlined for manufactured drugs and psychotropic substances, including obtaining necessary licenses and permits. **Stakeholder:** General Public * **Impact:** Increased control and regulation of these substances aims to reduce potential misuse and harm to public health. * **Action Required:** Be aware of the updated regulations regarding the listed substances.

Key Entities Referenced

Narcotic Drugs and Psychotropic Substances Act, 1985: Indian law regulating narcotic drugs and psychotropic substances, being amended by this notification. Ministry of Finance (Department of Revenue): The issuing ministry and department responsible for this notification regarding manufactured and psychotropic drugs. New Delhi: Location where the notification was issued. Hexahydrocannabinol (HHC): A psychotropic substance being added to the Schedule of the Narcotic Drugs and Psychotropic Substances Act, 1985. Carisoprodol: A psychotropic substance being added to the Schedule of the Narcotic Drugs and Psychotropic Substances Act, 1985.
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रजिस्ट्री स.ं डी.एल.- 33004/99 REGD. No. D. L.-33004/99 सी.जी.-डी.एल.-अ.-18022026-270264 xxxGIDHxxx CG-DLxx-ExG-I1D8E0x2x2x0 26-270264 असाधारण EXTRAORDINARY भाग II—खण् ड 3—उप-खण्ड (ii) PART II—Section 3—Sub-section (ii) प्राजधकार स ेप्रकाजित PUBLISHED BY AUTHORITY स.ं 865] नई दिल्ली, बुधिार, फरिरी 18, 2026/माघ 29, 1947 No. 865] NEW DELHI, WEDNESDAY, FEBRUARY 18, 2026/MAGHA 29, 1947 जित्त मत्रं ालय (रािस्ट्ि जिभाग) अजधसचू ना नई दिल्ली, 18 फरिरी, 2026 का.आ. 905(अ).— केंद्र सरकार, स्ट्िापक औषजध और मन:प्रभािी पिार्थ अजधजनयम, 1985 (1985 का 61) की धारा 2 के खंड (xi) के उप-खंड (ख) म ेंप्रित्त िजियों का प्रयोग करत े हुए एतिद्वारा जनम्नजलजखत पिार्ों, लिणों तर्ा उनस े तैयार की गई िस्ट्तओंु को जनर्मतथ औषजध घोजषत करता ह,ै अर्ाथत्:- (i) एन-पाइरोजलजडनो प्रोटोजनटाजीन (प्रोटोजनटाजेपाइन)- 2-[(4-प्रोपोक्सीदफनाइल) जमर्ाइल]-5-नाइरो-1-(2-पाइरोजलजडन-1-इलर्े ाइल)-1एच बेंिोइजमडािोल; (ii) एन-पाइरोजलजडनो मेटोजनटाजीन (मेटोजनटाजेपाइन)- 2-[(4-मर्े ॉक्सीदफनाइल) जमर्ाइल]-5-नाइरो-1-(2-पाइरोजलजडन-1-इलेर्ाइल)-1एच-बेंिोइजमडािोल; 1253 GI/2026 (1)2 THE GAZETTE OF INDIA : EXTRAORDINARY [PART II—SEC. 3(ii)] (iii) एटोजनटाजेजपप्ने (एन-जपपेररजडनाइल एटोजनटाजीन)- 2-[(4-एर्ोक्सीदफनाइल) जमर्ाइल]-5-नाइरो-1-(2-जपपेररजडन-1-इलेर्ाइल)-1एच- बेंिोइजमडािोल; (iv) एन-डेजसर्ाइल - आइसोटोजनटाजीन (नोररसोटोजनटाजीन)- एन-एर्ाइल-2-[[4-(1-जमर्ाइलएर्ॉक्सी)दफनाइल]जमर्ाइल]-5-नाइरो-1एच-बेंजिजमडाजोल-1-एर्ेनमाइन। 2. यह अजधसूचना आजधकाररक रािपत्र म ेंप्रकाजित होन े की तारीख स ेलाग ू होगी। [फा. स.ं एन-12019/1/2025-एनसी-II-डीओआर] मुकेि सुंिररयाल, अिर सजचि MINISTRY OF FINANCE (Department of Revenue) NOTIFICATION New Delhi, the 18th February, 2026 S.O. 905(E).— In exercise of the powers conferred by sub-clause (b) of clause (xi) of section 2 of the Narcotic Drugs and Psychotropic Substances Act, 1985 (61 of 1985), the Central Government hereby declares the following substances, salts and preparations thereof to be manufactured drugs, namely: - (i) N-Pyrrolidino protonitazene (protonitazepyne)- 2-[(4-Propoxyphenyl) methyl]-5-nitro-1-(2-pyrrolidin-1-ylethyl)-1H-benzoimidazole; (ii) N-pyrrolidino metonitazene (metonitazepyne)- 2-[(4-methoxyphenyl) methyl]-5-nitro-1-(2-pyrrolidin-1-ylethyl)-1H-benzoimidazole; (iii) Etonitazepipne (N-piperidinyl etonitazene) – 2-[(4-Ethoxyphenyl) methyl]-5-nitro-1-(2-piperidin-1-ylethyl)-1H-benzoimidazole; (iv) N-Desethyl-isotonitazene (norisotonitazene) – N-Ethyl-2-[[4-(1-methylethoxy) phenyl] methyl]-5-nitro-1H-benzimidazole-1-ethanamine. 2. This notification shall come into force from the date of its publication in the Official Gazette. [F. No N-12019/1/2025-NC-II-DOR] MUKESH SUNDRIYAL, Under Secy.[भाग II—खण् ड 3(ii)] भारत का रािपत्र : असाधारण 3 अजधसचू ना नई दिल्ली, 18 फरिरी, 2026 का.आ. 906(अ).— चूूँदक केन्द्द्र सरकार जनम्नजलजखत पिार्ों (प्राकृजतक या कृजत्रम) या प्राकृजतक सामग्री या दकसी लिण या ऐस ेपिार्ों या सामजग्रयों के जनमाथण के िरुु पयोग की प्रकृजत और प्रभाि या िरुु पयोग के िायरे के संबंध म,ें और ऐस े पिार्ों के संबंध म ेंसंिोधन और ऐस ेपररितनथ िो संयुि राष्ट्र मन:प्रभािी पिार्थ सम्मले न, 1971 म ेंिाजमल दकए गए ह,ैं के आधार पर उपलब्ध िानकारी और साक्ष्य स ेसंतष्टु ह,ै और िह जनम्नजलजखत पिार्ों या प्राकृजतक सामजग्रयों या लिण या ऐसे पिार्ों या सामजग्रयों के जनमाथण को स्ट् िापक औषजध एि ंमन:प्रभािी पिार्थ अजधजनयम, 1985 (1985 का 61), (जिसे इसके बाि उि अजधजनयम कहा िाएगा) की अनुसूची म ेंजिजनर्िथष्ट मन:प्रभािी पिार्ों की सूची म ें िोड़ना अजनिाय थ मानती ह।ै अतः, अब, उि अजधजनयम की धारा 3 द्वारा प्रित्त िजियों का प्रयोग करत े हुए, केंद्र सरकार इस प्रकार उि अजधजनयम की अनुसूची म ें जनर्िथष्ट मन:प्रभािी पिार्ों की सूची म ें जनम्नजलजखत अजतररक्त सिं ोधन करती ह,ै अर्ाथत:् - उि अजधजनयम की अनुसूची म ें क्रम संख्या 110 िेड िेड आई के बाि और उससे संबंजधत प्रजिजष्टयों के बाि जनम्नजलजखत क्रम संख्या और प्रजिजष्टयाूँ क्रमिः सजम्मजलत की िाएंगी, अर्ाथत:् - क्रम स.ं अंतरराष्ट्रीय गैर-स्ट्िाजमत्ि अन्द् य गैर-स्ट्िाजमत्ि िाले नाम रासायजनक नाम िाले नाम “110 िडे हक्े साहाइड्रोकैनाजबनोल 6,6,9-राइजमर्ाइल-3-पेंटाइल- (एच.एच.सी.) िेड ि े 6ए,7,8,9,10,10ए- हक्े साहाइड्रोबेंजो[सी]क्रोमेन-1-ओल 110 िेड कैरीसोप्रोडल 2-[(काबाथमायलॉक्स ी)जमर्ाइल]-2- िेड के जमर्ाइलपेंटाइल(1- इर्ाइलएजर्ल)काबाथमेट” 2. यह अजधसूचना आजधकाररक रािपत्र म ेंप्रकाजित होन े की तारीख स ेलाग ू होगी। [फा. स.ं एन-12019/1/2025-एनसी-II-डीओआर] मुकेि सुंिररयाल, अिर सजचि नोटः स्ट् िापक औषजध एिं मन:प्रभािी पिार् थ अजधजनयम, 1985 (1985 का 61) की अनुसूची को पहली बार दिनांक 26 अक्टूबर, 1992 के संख्या का.आ.785(अ) द्वारा सिं ोजधत दकया गया र्ा और बाि म ेंसंख्या का.आ.49(अ) दिनांक 8 िनिरी, 1993, संख्या का.आ.39(अ) दिनांक 12 िनिरी, 1996, संख्या का.आ.475(अ) दिनांक 11 िून, 2003, संख्या सा.का.जन. 621(अ) दिनांक 1 अगस्ट्त, 2003, संख्या सा.का.जन. 1(अ) दिनांक 2 िनिरी, 2004, संख्या का.आ.311(अ) दिनांक 10 फरिरी, 2011, संख्या का.आ.376(अ) दिनांक 5 फरिरी, 2015, संख्या का.आ.2374(अ) दिनांक 12 िुलाई, 2016, संख्या का.आ.1383(अ) दिनांक 2 मई, 2017, संख्या का.आ.821(अ) दिनांक 27 फरिरी, 2018, सख्ं या का.आ.1761(अ) दिनांक 26 अप्रैल, 2018 और संख्या का.आ.3448(अ) दिनांक 13 िलु ाई, 2018, संख्या का.आ.1352(अ)4 THE GAZETTE OF INDIA : EXTRAORDINARY [PART II—SEC. 3(ii)] दिनांक 13 माच थ 2019, संख्या का.आ.1275(अ) दिनांक 23 माच थ 2021, संख्या का.आ.4428(अ) दिनांक 22 जसतंबर 2022, संख्या का.आ.5319(अ) दिनांक 16 निंबर, 2022, संख्या का.आ.578(अ) दिनांक 8 फरिरी, 2024 और संख्या का.आ.1730(अ) दिनांक 16 अप्रैल, 2025 द्वारा संिोजधत दकया गया। NOTIFICATION New Delhi, the 18th February, 2026 S.O. 906(E).— WHEREAS the Central Government is satisfied, on the basis of information and evidence which has become available to it, with respect to the nature and effects of, or the scope of abuse of the following substances (natural or synthetic) or natural material or any salt or preparation of such substances or materials, and the modification with respect to such substances and the changes that have been incorporated in the United Nations Convention on Psychotropic Substances, 1971, and that it is necessary to add the following substances or natural materials or salts or preparation of such substances or materials in the list of psychotropic substances specified in the Schedule to the Narcotic Drugs and Psychotropic Substances Act, 1985 (61 of 1985) (hereinafter referred to as the said Act). NOW, THEREFORE, in exercise of the powers conferred by section 3 of the said Act, the Central Government hereby makes the following further amendments in the list of psychotropic substances specified in the Schedule to the said Act, namely: - In the said Act, in the Schedule, after serial number 110ZZI and the entries relating thereto, the following serial numbers and entries shall, respectively be inserted, namely: - Sl. No. International non- Other non-proprietary names Chemical Name Proprietary names “110ZZJ Hexahydrocannabinol (HHC) 6,6,9-Trimethyl-3-pentyl- 6a,7,8,9,10,10a- hexahydrobenzo[c]chromen-1-ol 110ZZK Carisoprodol 2-[(carbamoyloxy)methyl]-2- methylpentyl(1- ethylethyl)carbamate” 2. This notification shall come into force from the date of its publication in the Official Gazette. [F. No N-12019/1/2025-NC-II-DOR] MUKESH SUNDRIYAL, Under Secy. Note: The Schedule to the Narcotic Drugs and Psychotropic Substances Act, 1985 (61 of 1985) was first amended, vide number S.O. 785(E), dated the 26th October, 1992 and subsequently amended, vide numbers S.O. 49(E), dated the 8th January, 1993, S.O. 39(E), dated the 12th January, 1996, S.O. 475(E), dated the 11th June, 2003, G.S.R. 621(E), dated the 1st August, 2003, G.S.R. 1(E), dated the 2nd January, 2004, S.O. 311 (E), dated the 10th February, 2011, S.O. 376(E), dated the 5th February, 2015, S.O. No. 2374 (E), dated the 12th July, 2016, S.O. No. 1383 (E), dated the 2nd May, 2017, S.O. 821(E), dated the 27th February, 2018, S.O. 1761(E), dated the 26th April, 2018 and S.O. 3448(E) dated the 13th July, 2018, S.O. 1352(E), dated the 13th March 2019, S.O. 1275(E), dated the 23rd March 2021, S.O. 4428(E), dated the 22nd September 2022, S.O. 5319 (E), dated the 16th November, 2022, S.O. 578(E), dated the 8th February, 2024 and S.O. 1730(E) dated 16th April, 2025.[भाग II—खण् ड 3(ii)] भारत का रािपत्र : असाधारण 5 अजधसचू ना नई दिल्ली, 18 फरिरी, 2026 का.आ. 907(अ).— केंद्र सरकार, स्ट्िापक औषजध और मन:प्रभािी पिार्थ अजधजनयम, 1985 (1985 का 61) की धारा 2 के खडं (viiक) और (xxiiक) द्वारा प्रित्त िजियों का प्रयोग करते हुए, जित्त मंत्रालय, रािस्ट्ि जिभाग म ेंभारत सरकार की अजधसूचना म ें जनम्नजलजखत अजतररि संिोधन करती ह,ै िो भारत के रािपत्र, असाधारण, भाग II, खंड 3, उप-खंड (ii) संख्या का.आ. 1055 (अ), दिनांक 19 अक्टूबर, 2001 म ें प्रकाजित हुई ह,ै अर्ाथत्:- उि अजधसूचना की, ताजलका म,ें क्रम संख्या 238 जडे जेडजडे एल और उससे संबंजधत प्रजिजष्टयों के बाि, जनम्नजलजखत क्रम संख्या और प्रजिजष्टयाूँ क्रमिः डाली िाएंगी, अर्ाथत:् - क्रम सं. मािक औषजध और अन्द्य गैर-स्ट्िाजमत्ि िाले रासायजनक नाम छोटी मात्रा मन:प्रभािी पिार्थ नाम (ग्राम में) िाजणजययक का नाम (ससंगल डोि मात्रा (ग्राम (अंतरराष्ट्रीय गैर- ग्राम में X में) छोटी स्ट्िाजमत्ि नाम मात्रा ग्राम 100) (आईएनएन)) में X 50) “238जेडजेडजेडएम एन-पाइरोजलजडनो 2[(4-प्रोपोफेजनल)जमर्ाइल]-5- 0.0017ग्राम 0.085ग्राम प्रोटोजनटाजीन नाइरो-1-(2-पाइरोजलजडन-1- (प्रोटोजनटाजेपाइन) इर्ाइल)-1एच-जबमैजोरटस्ट्सीन 238जेडजेडजेडएन एन-पाइरोजलजडनो 2[(4-मेर्ॉक्सीफेजनल)जमर्ाइल]- 0.50ग्राम 25ग्राम मेटोनाइटेजीन 5-नाइरो-1-(2-पाइरोजलजडन-1- (मेटोनाइटेजपाइन)- इर्ाइल)-1एच- जबमैजेजनओफॉरमाइड 238जेडजेडजेडओ ईटोजनटाजेजपपने 2[(4-इर्ॉक्सीफेजनल)जमर्ाइल]- 0.0075 ग्राम 0.375ग्राम (एन-पाइपेररजडजनल 5-नाइरो-1-(2-पाइपेररडीन-1- ईटोजनटाजीन) इर्ाइल)-1एच-जबमैजेजनडोरो 238जेडजेडजेडपी एन-डेसेजर्ल- एन-एजर्ल-2-[[4-(1- 0.01ग्राम 0.5 ग्राम आइसोटोजनटािीन मेजर्लएर्ोक्सी)फेजनल]जमर्ाइल] (नोररसोटोजनटािी) -5-नाइरो-1एच-बेंजजजमडाजोल- 1-एर्ेनामीन 238जेडजेडजेडक्यू हक्े साहाइड्रोकैनाजबनोल 6,6,9-राइजमर्ाइल-3-पेंरटल- 0.5ग्राम 25ग्राम (एच.एच.सी.) 6ए,7,8,9,10,10ए- हक्े साहाइड्रोबेंजो[सी]क्रोमेन-1- ओल6 THE GAZETTE OF INDIA : EXTRAORDINARY [PART II—SEC. 3(ii)] 238 जेडजेडजेडआर कैरीसोप्रोडल 6,6,9-राइजमर्ाइल-3-पेंटाइल- 25 ग्राम 1250ग्राम” 6ए,7,8,9,10,10ए- हक्े साहाइड्रोबेंजो[सी]क्रोमेन-1- ओल 2. यह अजधसूचना आजधकाररक रािपत्र म ेंप्रकाजित होन े की तारीख स ेलाग ू होगी। [फा. स.ं एन-12019/1/2025-एनसी-II-डीओआर] मुकेि सुंिररयाल, अिर सजचि नोट: मलू अजधसूचना भारत के रािपत्र, असाधारण, भाग-II, खंड-3, उपखंड (ii) म ें संख्या का.आ. 1055 (अ), दिनांक 19 अक्टूबर, 2001 द्वारा प्रकाजित की गई र्ी और बाि म ें संख्या का.आ. 2941 (अ), दिनांक 18 निंबर, 2009, का.आ. 1430 (अ), दिनांक 21 िून, 2011, का.आ. 375 (अ) दिनांक 5 फरिरी, 2015, का.आ. 2375(अ), दिनांक 12 िुलाई, 2016, का.आ. 384 (अ), दिनांक 2 मई, 2017, का.आ. 822(अ), दिनांक 27 फरिरी, 2018, का.आ. 1762(अ), दिनांक 26 अप्रैल, 2018, का.आ. 1351 (अ), दिनांक 13 माच थ 2019, का.आ. 1276 (अ), दिनांक 23 माच थ 2021, का.आ. 4429 (अ), दिनांक 22 जसतंबर 2022, का.आ. 5320 (अ), दिनांक 16 निंबर, 2022 का.आ. 578(अ), दिनांक 8 फरिरी, 2024 और का.आ. 1731 (अ) दिनांक 16 अप्रलै , 2025 द्वारा संिोजधत की गई र्ी। NOTIFICATION New Delhi, the 18th February, 2026 S.O. 907(E).— In exercise of the powers conferred by clauses (viia) and (xxiia) of section 2 of the Narcotic Drugs and Psychotropic Substances Act, 1985 (61 of 1985), the Central Government hereby makes the following further amendments in the notification of the Government of India in the Ministry of Finance, Department of Revenue, published in the Gazette of India, Extraordinary, Part II, Section 3, Sub-section (ii) vide number S.O. 1055 (E), dated the 19th October, 2001, namely:- In the said notification, in the Table, after serial number 238 ZZZL and the entries relating thereto, the following serial numbers and entries shall, respectively be inserted, namely: - S. No. Name of Narcotic Other non-proprietary Chemical name Small Commercial Drug and names Quantity Quantity Psychotropic (in gm.) (in gm.) Substance (Single dose (Small (International non- in gm X 100) quantity in proprietary names gm X 50) (INN)) “238ZZZM N-Pyrrolidino 2-[(4-Propoxyphenyl)methyl]- 0.0017gm 0.085gm protonitazene 5-nitro-1-(2-pyrrolidin-1- (protonitazepyne) ylethyl)-1H-benzoimidazole 238ZZZN N-pyrrolidino 2-[(4-methoxyphenyl)methyl]- 0.50gm 25gm metonitazene 5-nitro-1-(2-pyrrolidin-1- (metonitazepyne)- ylethyl)-1H-benzoimidazole[भाग II—खण् ड 3(ii)] भारत का रािपत्र : असाधारण 7 238ZZZO Etonitazepipne 2-[(4-Ethoxyphenyl)methyl]- 0.0075 gm 0.375gm (N-piperidinyl 5-nitro-1-(2-piperidin-1- etonitazene) ylethyl)-1H-benzoimidazole 238ZZZP N-Desethyl- N-Ethyl-2-[[4-(1- 0.01gm 0.5 gm isotonitazene methylethoxy)phenyl]methyl]- (Norisotonitazene) 5-nitro-1H-benzimidazole-1- ethanamine 238ZZZQ Hexahydrocannabinol 6,6,9-Trimethyl-3-pentyl- 0.5gm 25gm (HHC) 6a,7,8,9,10,10a- hexahydrobenzo[c]chromen- 1-ol 238ZZZR Carisoprodol 2-[(carbamoyloxy)methyl]-2- 25 gm 1250gm” methylpentyl(1- ethylethyl)carbamate 2. This notification shall come into force from the date of its publication in the Official Gazette. [F. No N-12019/1/2025-NC-II-DOR] MUKESH SUNDRIYAL, Under Secy. Note: The principal notification was published in the Gazette of India, Extraordinary, Part II, Section 3, Sub-section (ii), vide number S.O. 1055 (E), dated the 19th October, 2001 and subsequently amended vide numbers S.O. 2941 (E), dated the 18th November, 2009, S.O. 1430 (E), dated the 21st June, 2011, S.O. 375 (E) dated the 5th February, 2015, S.O. 2375(E), dated the 12th July, 2016, S.O. 384 (E), dated the 2nd May, 2017, S.O. 822(E), dated the 27th February, 2018, S.O. 1762(E), dated the 26th April, 2018, S.O. 1351 (E), dated the 13th March 2019, S.O. 1276 (E), dated the 23rd March 2021, S.O. 4429 (E), dated the 22nd September 2022, S.O. 5320 (E), dated 16th November, 2022 S.O. 578(E), dated the 8th February, 2024 and S.O. 1731 (E) dated 16th April, 2025. Uploaded by Dte. of Printing at Government of India Press, Ring Road, Mayapuri, New Delhi-110064 and Published by the Controller of Publications, Delhi-110054.

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