Home India Ministry of Health and Family Welfare Classification in IVD medical devices under the provision of...
Date: 2021-07-23 Category: Not Applicable State: Union Government Country: India

Classification in IVD medical devices under the provision of MD Rules 2017

Issued by Ministry of Health and Family Welfare · Central Drugs Standard Control Organization

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Executive Summary & Key Takeaways

**Executive Summary:** This notice from the Drugs Controller General of India classifies In-Vitro Diagnostic (IVD) Medical Devices under the Medical Devices Rules, 2017. It aims to regulate the safety, quality, and performance of IVDs. The classification is based on intended use, risk, and other parameters as specified in the First Schedule of the Medical Devices Rules, 2017 and is effective as of July 23, 2021. **Key Points / Main Content:** * **Regulatory Framework:** * The Drugs and Cosmetics Act, 1940, and the Medical Devices Rules, 2017, regulate the safety, quality, and performance of Medical Devices and In-Vitro Diagnostic Medical Devices. * The Medical Devices Rules, 2017 were implemented from January 1, 2018. * **Classification of IVDs:** * The Drugs Controller General of India classifies IVDs based on intended use, risk associated with the device, and parameters in the First Schedule of the Medical Devices Rules, 2017, under subrule 3 of rule 4. * Lists of classified IVDs are provided in Annexure A (IVD Analyzers), Annexure B (IVD Instruments), and Annexure C (IVD Software). * **Guidance and Revisions:** * The classification list is intended as guidance for applicants importing or manufacturing medical devices under the Medical Devices Rules, 2017. * The classification list is dynamic and subject to revision under the Medical Devices Rules, 2017. **Impact Analysis** **Applicants for Import or Manufacture of Medical Devices:** * Impact: * Need to understand the classification of their specific IVD devices according to Annexure A, B, and C to comply with the Medical Devices Rules, 2017. * Action Required: * Review Annexure A, B and C to determine the correct classification for their IVD devices. * Ensure applications for import or manufacture align with the classifications in the provided lists. **CDSCO (Central Drugs Standard Control Organisation) Website Users:** * Impact: * The classification list is available on the CDSCO website for reference. * Action Required: * Consult the CDSCO website for the most up-to-date classification list, as it is subject to revisions.

Key Entities Referenced

Drugs Controller General India: Regulatory authority responsible for medical devices and pharmaceuticals. Directorate General of Health Services: A government organization associated with health services. Medical Devices Rules, 2017: The regulatory framework governing medical devices in India. Drugs and Cosmetics Act, 1940: The primary legislation governing drugs and cosmetics in India, under which medical devices are also regulated. Drugs Technical Advisory Board: An advisory board consulted by the Central Government on matters related to drug regulation. InVitro Diagnostic Medical Devices: Medical devices used for in vitro diagnostics, regulated under the Medical Devices Rules, 2017. Central Government: The governing body responsible for implementing the Medical Devices Rules, 2017. New Delhi: The location of the Drugs Controller General India office in India.
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Drugs Controller General (India) Directorate General of Health Services FDA Bhawan, Kotla Road, New Delhi NOTICE File No. |VD/Misc/196/2020 Date: 49 3 JUL 2021 Subject: Classification of In-vitro Diagnostic Medical Devices under the provisions of Medical Devices Rules, 2017 - Regarding. Safety, quality and performance of Medical Devices and /n-vitro Diagnostic Medical Devices are regulated under the provisions of the Drugs and Cosmetics Act, 1940 and rules, made there under. For the regulation of Medical Devices and /n-vitro Diagnostic Medical Devices with respect to the import, manufacture, clinical investigation, clinical performance evaluation, sale and distribution, the Central Government, after consultation with the Drugs Technical Advisory Board, has notified Medical Devices Rules, 2017 vide G.S.R. 78(E) dated 31.01.2017 which is already implemented from 01.01.2018. In this connection, in exercise of the powers conferred under sub-rule (3) of rule 4 of Medical Devices Rules, 2017, the undersigned hereby classifies the In-vitro Diagnostic Medical Devices based on the intended use, risk associated with the device and other parameters specified in the First Schedule. List of In-vitro Diagnostics Medical Devices placed at Annexure A, Annexure B and Anne 1.x u Gr ee n C er ais l s u ib nj te ec nt de ed d t uo s t eh e g if vo el nlo w ai gn ag is n: st each of the device is for guidance to the applicants who intends to furnish application of import or manufacture of medical Devices under the provisions of Medical Devices Rules, 2017. However, as device may have specified intended use as specified by its 2. Tm ha in su f la isc tt u isr e dr y. namic and is subjected to revision from time to time under the provisions of the Medical Devices Rules, 2017. w (Dr. V.G. Somani) Drugs Controller General of India To, CDSCO WebsiteAnnexure A File No. IVD/Misc/196/2020 Drugs Controller General (India) Directorate General of Health Services FDA Bhawan, Kotla Road, New Delhi Date: 2 3 JUL 2021 List of In-Vitro Diagnostic Medical Devices (IVD Analyzers) under provisions of sub-rule (2) rule 4 of the Medical Devices Rules, 2017 Sr. Category Name of the Risk Intended use No. In-Vitro Class as Diagnostic per Medical Devices Part Il, (IVD Analyzers) First Schedule of MDR 2017 1 | Clinical Alcohol body-fluid A An analyzer intended to determine the chemistry analyser concentration of alcohol in a body- fluid specimen. Cc An analyzer intended to be used for near-patient testing to determine the concentration of alcohol in a body- fluid specimen. 2 Amino acid A An analyzer intended to be used for analyser the qualitative and/or quantitative in vitro determination of individual amino acids in a protein sample obtained from a clinical specimen. 3 Bilirubinometry A A device that measures directly or analyser indirectly the bilirubin concentration in blood or other samples. Cc A device intended to be used for near- patient testing that measure directly or indirectly the bilirubin concentration in blood or other samples. 4 Catecholamines A A device that measures analyser catecholamine concentration in biological samples. 5 | Chemiluminescent A An analyzer intended to be used for immunoassay the qualitative and/or quantitative in analyser vitro determination of chemical and/or biological markers in a clinical specimen. Page 1 of 8(Gr. | Category Name of the Risk Intended use No. In-Vitro Class as Diagnostic per Medical Devices Part Il, (IVD Analyzers) First Schedule of MDR 2017 6 | Clinical Chloride A An analyzer intended to be used for chemistry coulometric titration the quantitative measurement of analyser chloride in a clinical specimen using a coulometric titration. 7 Cholesterol A A device that measures the analyser cholesterol in serum/whole blood. 8 Clinical chemistry A An analyzer intended to be used for analyser the qualitative and/or quantitative determination of one or multiple clinical chemistry analytes in a clinical specimen. 9 Creatinine analyser A A device that measures creatinine concentration in urine or serum sample. 10 Enzyme analyser A A device that measures the enzymatic activity of the sample for diagnosis. 11 Glycated A An analyzer intended to be used for haemoglobin the quantitative measurement of (HbA1C) analyser glycated haemoglobin (HbA1c) ina clinical specimen. 12 High performance A An analyzer designed to use high liquid performance liquid chromatography chromatography (HPLC) for the qualitative and/or analyser quantitative in vitro determination of chemical and/or biological markers in a clinical specimen. 13 Identification and A A device that identifies Antibiotic infectious/pathogenic microorganisms susceptibility by photometry such as absorption, analyser fluorescence and luminescence, and measures the susceptibility to therapeutic drugs. 14 lon-selective A An analyzer intended to be used for analyser the quantitative measurement of electrolytes and/or other ions in a clinical specimen. 15 Lactate analyser A An analyzer used to determine the concentration of lactate in various body fluids using the lactate oxidase fixation electrode. Page 2 of 8or. Category Name of the Risk Intended use No. In-Vitro Class as Diagnostic per Medical Devices Part Il, (IVD Analyzers) First Schedule of MDR 2017 16 Clinical Lipid profile A An analyzer intended to be used for chemistry analyser the qualitative and/or quantitative in vitro determination of lipid profile analytes in a clinical specimen. 17 Nitrogen body- An analyzer used to analyse the fluid-sample nitrogen (N2) content in a body fluid. analyser 18 Protein analyser A device used to measure concentration and to identify specific proteins present in a clinical specimen. 19 Radioimmunoassa An analyzer intended to be used for y analyser the qualitative and/or quantitative in vitro determination of chemical and/or biological markers in a clinical specimen using an immunological method which utilizes a radiometric detection system to detect the presence of immune complexes labelled using a radioisotope. 20 Urine analyser An analyzer intended to be used for the qualitative and/or quantitative in vitro determination of various chemical and cellular constituents of a clinical urine specimen. An analyzer intended to be used for near-patient testing for the qualitative and/or quantitative in vitro determination of various chemical and cellular constituents of a clinical urine specimen. 21 Hematology ABO/Rh(D) blood A lab based analyzer (other than grouping analyser near-patient testing) intended to be used to perform blood group testing to determine the ABO and Rh(D) status of clinical specimens. An analyzer (for near-patient testing) intended to be used to perform blood group testing to determine the ABO and Rh(D) status of clinical specimens. Page 3 of 8Intended use Sr. | Category Name of the Risk In-Vitro Class as No. Diagnostic per Medical Devices Part Il, (IVD Analyzers) First Schedule of MDR 2017 A device that quantifies the formed 22 | Hematology Blood cell count A elements in the blood (i. e. , analyser erythrocytes, leukocytes, and platelets) by electroimpedance, optical scattering or dye binding. An analyzer intended to be used for 23 Blood coagulation the qualitative and/or quantitative in analyser vitro determination of one or multiple coagulation components involved in haemostasis in a clinical specimen. An analyzer intended to be used for near-patient testing for the qualitative and/or quantitative in vitro determination of one or multiple coagulation components involved in haemostasis in a clinical specimen. An analyzer intended to be used to 24 Blood perform pre-transfusion blood group group/antibody testing, red cell antibody screening analyser screening/identification and/or red cell phenotyping of clinical specimens or donor specimens in order to determine suitability for transfusion or transplantation. An analyzer intended to be used for 25 Co-oximetry the quantitative in vitro measurement analyser of oxygen saturation, haemoglobin derivatives and other calculated haemoximetry parameters in a whole blood specimen. An analyzer intended to be used to 26 Erthrocyte determine the erythrocyte sedimentation rate sedimentation rate (ESR) of red blood (ESR) analyser cells in an anticoagulated whole blood specimen. An analyzer intended to be used to 27 Flow cytometry count, examine and/or sort cells or analyser microscopic particles in a clinical specimen. A device that measures heparin 28 Heparin analyser concentration in blood samples. Page 4 of 8( 3r. | Category Name of the Risk Intended use No. In-Vitro Class as Diagnostic per Medical Devices Part Il, (IVD Analyzers) First Schedule of MDR 2017 29 | Hematology | Osmotic fragility A An analyzer intended to be used for analyser the determination of the osmotic fragility of red blood cells in a whole blood specimen. 30 Reticulocyte A An analyzer intended to be used for analyser the qualitative and/or quantitative in vitro determination of reticulocytes, or immature red blood cells in a clinical specimen. 31 Blood gas analyser A An analyzer intended to be used for the quantitative in vitro measurement of blood pH, partial pressure of oxygen (pO2) and/or partial pressure of carbon dioxide (pCO2), and the calculation of other blood gas parameters in a clinical specimen. Cc An analyzer intended to be used for near-patient testing for the quantitative in vitro measurement of blood pH, partial pressure of oxygen (pO2) and/or partial pressure of carbon dioxide (pCO2), and the calculation of other blood gas parameters in a Clinical specimen. 32 Haemoglobin A An analyzer intended to be used to analyser determine the concentration of haemoglobin in a clinical specimen. 33 Platelet A An analyzer intended to be used for aggregation the qualitative and/or quantitative in analyser vitro examination of platelet function in a clinical specimen, by inducing platelet aggregation through the addition of platelet aggregating agents. 34 | Immunology | Densitometry A An analyzer intended to be used for analyser the qualitative and/or quantitative in vitro determination of the staining pattern intensity on film, acetate or other composite medium to separate and/or visualize the individual components of a clinical specimen. Page 5 of 8(Sr. | Category Name of the Risk Intended use No. In-Vitro Class as Diagnostic per Medical Devices Part Il, (IVD Analyzers) First Schedule of MDR 2017 35 | Immunology | Enzyme A An analyzer intended to be used for immunoassay the qualitative and/or quantitative in (EIA) analyser vitro determination of chemical and/or biological markers, in a clinical specimen, using an immunological method. 36 Fluorescent A An analyzer intended to be used for immunoassay the qualitative and/or quantitative in analyser vitro determination of chemical and/or biological markers in a clinical specimen. 37 Immunology A An analyzer used to identify and analyzer detect the concentration of specific substances in a sample, using immunoassay methodologies. 38 Immunofluorescent A A device used to measures the analyser volume of antigen/antibody present in the components of body fluids. 39 Microarray A An analyzer intended to be used for analyser the in vitro determination of multiple target analytes in a single clinical specimen using oligonucleotide capture molecules arranged in a consistent pattern on a slide, chip or membrane. 40 Particle-counting A A device for immunological immunoassay measurement by counting latex analyser aggregates based on the light scattering. 41 Photometric A An analyzer, intended to be used to immunoassay scan an immunoassay reagent vehicle analyser after exposure to a clinical specimen, to provide a quantitative, semi- quantitative and/or qualitative in vitro determination of chemical substances and/or biological markers in a clinical specimen, using photometry. Page 6 of 8(Sr. | Category Name of the Risk Intended use No. In-Vitro Class as Diagnostic per Medical Devices Part Il, (IVD Analyzers) First Schedule of MDR 2017 42 | Microbiolog | Antimicrobial A An analyzer intended to be used for y susceptibility the in vitro determination of an analyser antimicrobial susceptibility profile by monitoring the growth rate of a microbiological organism from a clinical specimen and/or culture isolate when exposed to a range of antimicrobials. 43 Blood culture A An analyzer intended to be used for analyser the qualitative and/or quantitative in vitro determination of microorganism growth in a blood culture preparation or other clinical specimen, with or without subsequent identification of the organism. 44 Gene analyser A A device that analyzes the sequence information of nucleic acid molecules extracted from biological samples. 45 Immunoturbidimetri A A light scattering analyzer that c analyser quantifies the analytes in the body fluid by measuring the light scattering intensity from the immune complex generated in the reaction between analyte and antibody. 46 Microorganism A An analyzer intended to be used for identification the identification of bacteria and/or analyser yeast isolated from clinical specimens by characterizing their morphology, substrate utilization and/or biochemical reactivity, using growth detection technology. 47 Nucleic acid A An analyzer intended to amplify target amplification (PCR) deoxyribonucleic acid (DNA) or analyser ribonucleic acid (RNA) in a clinical specimen. 48 Yeast/fungi A An analyzer intended to be used for identification the identification of yeast and/or fungi analyser isolated from clinical specimens by characterizing their morphology, substrate utilization and/or biochemical reactivity, using growth detection technology. Page 7 of 8Osr. Category Name of the Risk Intended use No. In-Vitro Class as Diagnostic per Medical Devices Part Il, (IVD Analyzers) First Schedule of MDR 2017 Other In-Vitro Diagnostic Medical Devices (IVD Analyzers) 49 | Clinical Gas A An analyzer intended to be used for chemistry / chromatography the qualitative and/or quantitative in Microbiology | analyser vitro determination of chemical and/or / Toxicology biological markers in a clinical specimen. 50 | Clinical Mass spectrometry A An analyzer intended to be used for chemistry / analyser the qualitative and/or quantitative Microbiology/ determination of the chemical Hematology composition of a clinical specimen by ionizing the specimen and separating the resulting ions according to mass using an electrical and magnetic field. 51 | Clinical Nephelometry A An analyzer intended to be used for chemistry / immunoassay the qualitative and/or quantitative in Immunology | analyser vitro determination of chemical and/or biological markers in a clinical specimen using an immunological method which utilizes a nephelometric detection system. 52 | Gastroentero | Faecal occult blood A An analyzer intended to be used for logy and immunoassay the qualitative and/or quantitative in Urology analyser vitro determination of faecal occult blood, using an immunological method to detect or measure haemoglobin in a clinical stool (faeces) specimen. 53 | Obstetrical Spermatozoa/seme A An analyzer intended to be used for and n analyser the qualitative and/or quantitative in Gynecologic vitro examination of a semen al specimen to assess volume, spermatozoa concentration, motility and/or morphological characteristics. Page 8 of 8Annexure B File No. IVD/Misc/196/2020 Drugs Controller General (India) Directorate General of Health Services FDA Bhawan, Kotla Road, New Delhi Date: {2 3 JUL 2021 List of In-Vitro Diagnostic Medical Devices (IVD Instuments) under provisions of sub-rule (2) rule 4 of the Medical Devices Rules, 2017 Sr. Name of the Risk Class Intended use No. In-Vitro Diagnostic as per Medical Devices Part Il, (IVD Instruments) First Schedule of MDR 2017 1 | Blood smear cassette A A device designed to be inserted into an automated microscope slide processing instrument to create a blood smear on a microscope examination slide for subsequent staining and/or microscopic analysis. 2 | Blood smear instrument A A manual laboratory instrument intended to be used to create a blood smear on a microscope examination slide for subsequent staining and/or microscopic analysis. 3 | Blood tube mixer A An instrument intended to be used for the mixing of blood or other biological fluids contained in blood tubes or other similar specimen receptacles using continuous motion or agitation. 4 | Blood com ponent A A wh d oe lv ei c be l od oe ds i org n pe rd e vf io or u t sh le y s cee np ta rr ia ft ui go en d of separator blood into components for further processing or storage. It is typically used in a blood bank or transfusion centre, and is not donor or patient connected. 5 | Blood Collection Tube A A device, whether vacuum type or not, specifically intended for the primary containment of predetermined volume of blood derived from human or animal body. Page 1 of 3) Sr. Name of the Risk Class Intended use No. In-Vitro Diagnostic as per Medical Devices Part Il, (IVD Instruments) First Schedule of MDR 20 A1 7 An instrument intended to be used to | 6 | Cell washer separate red blood cells from whole blood and wash the intact red blood cells, to remove plasma, debris and/or any other extraneous material so they are free from interfering substances and suitable for use in subsequent in 7 | Colony counter A Avi t dr eo vc il cin ei c da el st ie gst ni en dg . to count bacterial colonies in a culture. 8 | Inoculating loop A A device intended to be used to transfer and spread inoculum from a clinical specimen and/or culture isolate into a culture medium for subsequent in vitro diagnostic processing and/or testing. 9 | Magnetic particle A A thn e i an us tt or mu ame tn et d i pn rt ee -n ad nae ld y tt io c b ale eu xs te rad c tfo ir on separation instrument of specific molecules from a clinical specimen using magnetic particle separation techniques. A A device intended to provide ideal 10 | Microbial conditions for microbial growth with an incubat or/imaging incubator, and to capture digital system images of the specimens contained within the incubator at specified time intervals. 41 | Microplate seal roller A A manually-operated device intended to firmly apply a seal to a microplate. 12 | Microplate washer A An instrument intended to be used for washing microplates. 13 | Microscope slide A An instrument intended to be used to apply a coverslip over a microscope coverslipper examination slide to protect the fixed/stained specimen from mechanical forces or environmental exposure prior to microscopic examination and/or long-term storage of the slide. Page 2 of 3Sr. Name of the Risk Class Intended use (an No. In-Vitro Diagnostic as per Medical Devices Part Il, (IVD Instruments) First Schedule of MDR 2017 14 | Microscope slide A An instrument intended to be used for hybridization/ the incubation of microscope slides for denaturation incubator the denaturation and/or hybridization of a Clinical specimen as part of an in situ hybridization (ISH) and/or fluorescence in situ hybridisation (FISH) protocol. 15 | Microscope slide A An instrument intended to be used to maker/stainer prepare, transfer or fix blood, tissue or other clinical specimens onto microscope examination slides, and then stain the slides using one or more biological or cytochemical staining solutions in preparation for subsequent microscopic analysis. 16 | Microscope slide A An instrument intended to be used for washing microscope slides by applying washer a flow of washing solution as part of the processing steps required to perform an in vitro diagnostic assay. 17 | Nucleic acid sample A An instrument intended to be used for preparation instrument the pre-analytical preparation of samples for downstream nucleic acid analysis. 18 | Slide-mounted-tissue A An assembly of devices designed to be dissection system used for dissection of microscope- slide-mounted tissue specimens under digital image guidance, allowing the user to digitally preselect the target dissection area with high precision. Excised tissues are suctioned into a sample tube for subsequent histopathology analysis. A An instrument or platform intended to 19 Specimen processing be used for the automated pre- instrument analytical preparation of a clinical specimen (excluding specimens for microbial culture), which may include the sampling, diluting, and/or aliquoting of clinical specimens and/or any post- analytical processing required, including labelling, storage and/or location data. Page 3 of 3Annexure C File No. IVD/Misc/196/2020 Drugs Controller General (India) Directorate General of Health Services FDA Bhawan, Kotla Road, New Delhi Date: 2 3 JUL 2021 List of In-Vitro Diagnostic Medical Devices (IVD Software) under provisions of sub-rule (2) rule 4 of the Medical Devices Rules, 2017 Intended use Sr. Name of the Risk No. | In-Vitro Diagnostic | Class as Medical Devices per (IVD Software) Part Il, First Schedule of MDR 1 Cancer cell 20Cc1 7 A software program with specific image analysis marker/morphology algorithms intended to be used in a digital pathology image-an alysis l ia mb mo ur na ot ho ir sy t t oo c has es mi is ct a lin l yt -h e o ra n ha il sy ts oi ls o go if cally-stained software clinical specimens for the quantitative detection of cell markers or changes in tissue architecture and/or cell morphological/physiological characteristics associated with any type of cancer, performed during in vitro diagnostic (IVD) testing. 2 Cancer risk Cc An interpretive software program intended to be used a ins ts ee rps rs em tie vn et s oftware uin s it nh ge Ia Vs Ds e rs es sum le tn st o fo f t hr eis k q uf ao lr i td ae tv ie vl e o ap ni dn /g o rc a qn uc ae nr t, i tb aty ive detection of one or multiple cancer-specific biomarkers in a clinical specimen. 3 Cardiovascular Cc An interpretive software program intended to be used risk/probabili ty cin a rt dh ie o va as ss ce us ls am r e cn ot n do if t ir oi nsk o/p rr eob va eb ni tl ,i t by y f o ur s ih na gv i rn eg s ua lts of a ins ts ee rps rs em tie vn et software the qualitative/quantitative clinical specimen in vitro diagnostic (IVD) tests. 4 Congenital Cc An interpretive software program intended to be used defect/synd rome risk cin o nt gh ee n ia ts as le s mes dm ie cn at l o df e r fi es ck t f aor n dt /h oe r p cr oe ns de itn ic oe n o of f a a foetus. assessment interpretive software in vitro diagnostic (IVD) results of various maternal/foetal biochemical, hormonal and/or ultrasound markers. Page 1 of 2o Sr. Name of the Risk Intended use No. In-Vitro Diagnostic Class as Medical Devices per (IVD Software) Part Il, First Schedule of MDR 2017 An interpretive software program intended to be used Human genomic Cc analysis interpretive for the analysis and visualization of human genome data from in vitro diagnostic (IVD) results obtained software through molecular genetic testing. It provides predictive and/or diagnostic information used in the assessment of adverse health condition risk, disease prevention, and/or health management. A software program intended to be used with an in vitro Laboratory diagnostic instrument/analyser or a data management instrument/analyser device connected to the IVD instrument/analyser, to application software facilitate user-controlled device function. An application software program intended to be used Microbial to identify microbial species (bacterial, fungal) using identification results from microbial cultures and laboratory interpretive software biochemical tests. Results from an in vitro diagnostic medical device (IVD) are input and the name(s), and reliability of possible microbial species returned. It is intended for use in a microbiology laboratory. An interpretive software program intended to be used Osteoporosis risk in the assessment of risk for developing osteoporosis. assessment This interpretive software program typically combines interpretive software patient demographics and the in vitro diagnostic (IVD) results of the qualitative and/or quantitative detection of one or multiple proteins in a tissue sample to establish an individual risk score that may be used to guide patient management. Note: Software, which drives a device or influences the use of a device, falls automatically in the same class. Software that is not incorporated in an in vitro diagnostic medical device, shall be classified using the classification provisions as specified in paragraph 2 of Part Il of First Schedule of Medical Devices Rules, 2017. Page 2 of 2

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