Home India Ministry of Health and Family Welfare Drug Alert for the Month of December 2024...
Date: 2025-01-24 Category: Not Applicable State: Union Government Country: India

Drug Alert for the Month of December 2024

Issued by Ministry of Health and Family Welfare · Central Drugs Standard Control Organization

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Executive Summary & Key Takeaways

What it means

  • The gazette notification is a monthly alert issued by the Central Drugs Standard Control Organisation (CDSCO) regarding drugs found to be Not of Standard Quality (NSQ).
  • The purpose is to inform stakeholders about NSQ batches identified in the market through continuous regulatory surveillance involving sample analysis from sales/distribution points.

Key Changes

  • A list of 51 drugs/products that have been declared as Not of Standard Quality (NSQ) for the month of December 2024 is provided.
  • The list includes the drug name, batch number, manufacturing and expiry dates, manufacturer's name and address, NSQ test results, and the name of the CDSCO laboratory that reported the results.
  • The NSQ results vary and include issues such as: Test of Clarity of solution, Particulate matter, Sterility, Dissolution, Assay of Phenylephrine Hydrochloride, Identification & Assay of Cholecalciferol, Uniformity of dispersion & Disintegration, Description, pH, Water content, Related Substances, Bacterial Endotoxins, and Uniformity of weight.
  • One product, Rabeprazole Injection IP (Batch AGI-23216), manufactured by M/s. Alliaance Biotech, is deemed spurious as per section 17B of the Drugs and Cosmetics Act due to failing multiple tests including Sterility, Clarity of Solution, Particulate matter, Identification, Assay of Rabeprazole Sodium and Description.
  • The products were tested by various CDSCO laboratories including Central Drugs Laboratory (Kolkata), Regional Drugs Testing Laboratory (RDTL) Guwahati, Central Drugs Testing Laboratory (CDTL) Chennai and CDTL Mumbai and RDTL Chandigarh.

Impact Analysis

Manufacturers

  • Suggested action: Implement stricter quality control measures, investigate the root cause of the NSQ findings, and take corrective and preventive actions (CAPA).

Distributors/Retailers

  • Suggested action: Verify inventory for the listed batch numbers, quarantine and return the affected products to the manufacturer, and ensure compliance with CDSCO directives.

Consumers/Patients

  • Suggested action: Consult healthcare professionals if they have used any of the listed drugs and experienced adverse effects. Report any adverse events to the appropriate authorities.

Regulatory Authorities

  • Suggested action: Conduct thorough investigations of the manufacturers, implement stricter penalties for non-compliance, and enhance collaboration with state drug control authorities.

Our Company

  • Review and strengthen our quality control processes to prevent similar issues from occurring in the future.

Key Entities Referenced

CDSCO: Central Drugs Standard Control Organisation, the national regulatory body for pharmaceuticals and medical devices in India. Drugs and Cosmetics Act, 1940: The primary legislation governing the import, manufacture, distribution, and sale of drugs and cosmetics in India. Section 17B of Drugs and Cosmetics Act: Defines 'spurious drugs' under the Drugs and Cosmetics Act, 1940. Central Drugs Laboratory, Kolkata: A CDSCO laboratory that tested several of the listed NSQ drugs. Regional Drugs Testing Laboratory (RDTL), Guwahati: A CDSCO laboratory that tested several of the listed NSQ drugs. Central Drugs Testing Laboratory (CDTL), Chennai: A CDSCO laboratory that tested several of the listed NSQ drugs. Central Drugs Testing Laboratory (CDTL), Mumbai: A CDSCO laboratory that tested several of the listed NSQ drugs. Regional Drugs Testing Laboratory (RDTL), Chandigarh: A CDSCO laboratory that tested several of the listed NSQ drugs.
Official Source Record View Original Source →
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NOT OF STANDARD QUALITY (NSQ) ALERT FOR THE MONTH OF DECEMBER – 2024 As part of the continuous regulatory surveillance, drug samples are picked from sales/distribution point, analyzed and list of Not of Standard Quality (NSQ) drugs are displayed on CDSCO portal on monthly basis. The purpose of displaying the NSQ list is to make stakeholders aware about the NSQ batches identified in the market. A. CDSCO/Central Laboratories S.No Product/Drug Batch No. Manufacturing Expiry Manufactured By NSQ Result Reported by Name Date Date CDSCO Laboratory 1. Cefotaxime DP24029 04/2024 03/2026 M/s. Bengal Chemicals Test of Clarity of Central Drugs Sodium Injection & Pharmaceuticals Ltd., solution, Laboratory, Kolkata IP 1 g At-620, Diamond Particulate matter Harbour Road, Behala Indl. Estate, Kolkata- 700034. 2. Meropenem A4ITX004 08/2024 07/2026 M/s. Shamshree Test of Clarity of Central Drugs Injection IP 500 Lifesciences Limited, solution, Laboratory, Kolkata mg (Merohuge Plot No. 11, Industrial Particulate matter 500 ) Area, Katha- Bhatolikalan, Baddi- 173205, H.P. 3. AMIKACIN 17800124 01/2024 12/2025 M/s. Karnataka Particulate Central Drugs SULPHATE Antibiotics And mattter and Laboratory, Kolkata INJECTION IP Pharmaceuticals Description 250 mg Limited, Plot No-14, (AMIKACIN Peenya II Phase, SULPHATE Bengaluru-560058, INJECTION IP Karnataka. 250 mg/ 2 ml for IM/IV Injection) 4. Rabeprazole AGI-23216 06/2023 05/2025 M/s. Alliaance Biotech, Sterility, Clarity of Central Drugs Injection IP 440/3, Vill-Katha, Solution, Laboratory, Kolkata Badddi, Solan (H.P.) - Particulate 173205 matter, Identification,Assay of Rabeprazole Sodium and Description”. The sample is deemed to be spurious as per section 17B of Drugs and Cosmetics Act 5. Rabeprazole AGI-23217 06/2023 05/2025 M/s. Alliaance Biotech, pH, Clarity of Central Drugs Injection IP 440/3, Vill-Katha, Solution, Laboratory, Kolkata Badddi, Solan (H.P.) - Particulate 173205 matter, Assay of Rabeprazole Sodium and Description 6. Tranexamic Acid 054A003 01/2024 12/2025 M/s. FDC Limited L-56 Related Central Drugs Tablets IP 500 & L-57, Phase-II-D Substances Laboratory, Kolkata mg (Clip 500 ) Verna Industrial Estate, Verna-403722, Salcete, Goa 7. Fexofenadine CT24250327 05/2024 04/2026 M/s.CMG BIOTECH Dissolution Central Drugs Hydrochloride A PVT.LTD, (Unit-II)Plot Laboratory, Kolkata Tablets IP No-58, Phase-III, (MANOFEX-180 ) Industrial Area, Sasarpur Terrace, HP- 176501 8. Rabeprazole MD23H20 08/2023 07/2025 M/s. Martin & Brown pH, Water, Clarity Central Drugs Sodium Injection Bio Sciences, K.No. of Solution, Laboratory, Kolkata IP 918/419, Malkumajra, Particulate Nalagarh Road, Baddi, matter, Assay of Dist. Solan (H.P.)- Rabeprazole 173205 Sodium and Description 9. Lignocaine G406 09/2024 08/2026 M/s. Gnosis pH Central Drugs Hydrochloride Gel Pharmaceuticals Pvt. Laboratory, Kolkata IP 5% w/v (30 g) Ltd., Nahan Road, Village Moginand, Kala- Amb, Distt.Sirmour,H.P.-173030 10. Cold Plus Syrup 4EL02283 09/2024 08/2027 M/s. Ciron Drugs & Assay of Central Drugs (Cold Plus Syrup) Pharmaceuticals Pvt. Phenylephrine Laboratory, Kolkata Ltd., N- Hydrochloride 118,119,113,119/1, 119/2 & 118/1, M.I.D.C., Tarapur, Boisar, Dist-Palghar- 401506, Maharashtra 11. Omeprazole 0ZI2415AC 06/2024 05/2026 M/s. CELON Test of Water by Central Drugs Lyophilized LABORATORIES PVT. KF Laboratory, Kolkata Powder for LTD., Plot No-2, Injection (I.V) ALEAP Industrial (OMERA 40mg Estate, Gajularamaram, Lyophilized Medchal District-500 Powder for 090, Telangana State, Injection ) India 12. BUPIVACAINE BCV22315 12/2023 11/2025 M/s. Nandani Medical Particulate Central Drugs HYDROCHLORI Laboratories Pvt. Ltd., mattter and Laboratory, Kolkata DE INJECTION 221/5, Bicholi Hapsi, Description IP 0.5% Kanadia Road, Indore 13. AXBEX A21410 05/2024 10/2025 M/s. Ozone Identification & Central Drugs Suspension Pharmaceuticals Ltd., Assay of Laboratory, Kolkata (Multivitamin Katha, Baddi-173205, Cholecalciferol Mulltimineral & Himachal Pradesh Antioxidant Suspension) 14. AXBEX A21411 05/2024 10/2025 M/s. Ozone Identification & Central Drugs Suspension Pharmaceuticals Ltd., Assay of Laboratory, Kolkata (Multivitamin Katha, Baddi-173205, Cholecalciferol Mulltimineral & Himachal Pradesh Antioxidant Suspension) 15. Thyroxine 16240148D 05/2024 04/2026 M/s. Macleods Dissolution Central Drugs Sodium tablets IP Pharmaceuticals Ltd., Laboratory, Kolkata (THYROX-25) Plot No-2209, GIDC, Sarigam, Dist-Valsad- 396155, Gujarat 16. Dexamethasone 119 06/2024 05/2026 M/s. Hindustan Free Central Drugs Sodium Medicines Pvt. Ltd., Dexamethasone, Laboratory, KolkataPhosphate BARAUNI-851112. Particulate Injection I.P. matter, Sterility, Extractable volume and Description 17. Amikacin L-24A-23I 01/2024 12/2025 M/s. Inmac Particulate Central Drugs Sulphate Injection Laboratories, mattter, Laboratory, Kolkata I.P. (AmikaVen- Bangsipura-142033 Assay/content of 500 Injection) (Pb) Amikacin and Description 18. Aspirin Gastro- ANET1121 08/2023 07/2025 M/s. Unicure India Ltd., Test of Central Drugs resistant Tablets C-21, 22 & 23, Sector- Dissolution Buffer Laboratory, Kolkata IP 75mg 3, Noida- 201301, Distt. Stage Gautam Budh Nagar (U.P.) 19. Absorbent Cotton 331 07/2024 06/2026 M/s. Vandana Surgi Acidity or Central Drugs Wool IP Pharma (P) Ltd., GA- alkalinity, Laboratory, Kolkata 26, RIICO Industrial Absorbency Area, Bijaynagar- Sinking Time, 305624, (Raj) Absorbency Water-holding Capacity, Foreign Fibres, Fluorescence, Water soluble substances, Neps and Sulphated ash 20. Noscapine, NGC-091 12/2023 11/2025 M/s.Medipol Description Central Drugs Chlorpheniramine Pharmaceuticals India Laboratory, Kolkata Maleate, Pvt. Ltd., 1199/3, Bhud, Guaiphenesin & Baddi, Dist-Solan, H.P., Sodium Citrate India Syrup 21. Diphenhydramine 40183 02/2024 01/2026 M/s. Zenith Drugs Assay of Menthol Central Drugs Hydrochloride, Limited 72/5 & 72/3, and Description Laboratory, Kolkata Ammonium 72/4, 74/1/1, 75/1/1, Chloride, Sodium Muradpura (Orangpura) Citrate & Menthol Dhar Road, Near Syrup (Beedryl Kalaria Indore 453001Plus) (MP), India 22. Bupivacaine 17B24005 09/2024 08/2026 M/s. Radiant pH and Bacterial Central Drugs Hydrochloride in Parenterals Ltd., 242/4, Endotoxins Laboratory, Kolkata Dextrose Injection 5 &6, G.I.D.C., Estate USP 4 ml at & Post Waghodia, Dist-Vadodara , Gujarat-391760 23. Bupivacaine 17B24004 06/2024 05/2026 M/s. Radiant pH, Bacterial Central Drugs Hydrochloride in Parenterals Ltd., 242/4, Endotoxins and Laboratory, Kolkata Dextrose Injection 5 &6, G.I.D.C., Estate Sterility USP 4 ml at & Post Waghodia, Dist-Vadodara , Gujarat-391760 24. Diphenhydramine 40186 02/2024 01/2026 M/s. Zenith Drugs Assay of Menthol Central Drugs Hydrochloride, Limited 72/5 & 72/3, and Description Laboratory, Kolkata Ammonium 72/4, 74/1/1, 75/1/1, Chloride, Sodium Muradpura (Orangpura) Citrate & Menthol Dhar Road, Near Syrup (Beedryl Kalaria Indore 453001 Plus) (MP), India 25. Telmisartan 23I-T2003 12/2023 11/2025 M/s. Orison Pharma Dissolution RDTL, Guwahati Tablets I.P.. International, Vill. Khari, (TELMOPI-40) Mauza Ogli, Kala Amb, Distt. Sirmour - 173030 (H.P.) 26. Acyclovir SRTH230874 08/2023 07/2025 M/s. SYSTOLE Uniformity of RDTL, Guwahati Dispersible B REMEDIES PVT. LTD., dispersion & Tablets IP Vill. Ogli, Kala Amb, Disintegration (Zovibact 800 Teh. Nahan, Distt. mg) Sirmour (H.P.) - 173 030 27. GLIMEPIRIDE SPT240261 02/2024 01/2026 M/s. SALUS Dissolution RDTL, Guwahati TABLETS IP PHARMACEUTICALS, (GLIMP-1) 480/211, Harraipur, PO Gurumajra, Teh. Baddi, Distt. Solan (H.P.) 173205 28. Zinc Sulphate LMT240811 07/2024 06/2026 M/s.Life Max Cancer Uniformity of RDTL, Guwahati Dispersible Laboratories, Plot No. dispersion & Tablets IP 20 mg 106 & 106 A, Sector6A, DisintegrationIIE, SIDCUL, Haridwar249403 (U.K) 29. Glimepiride LMT240339 03/2024 02/2026 M/s.Life Max Cancer Dissolution of RDTL, Guwahati Tablets I.P. 1 mg Laboratories, Plot No. Glimepiride 106 & 106 A, Sector6A, IIE, SIDCUL, Haridwar249403 (U.K) 30. INFUSION SET- KT-033 03/2024 02/2027 M/s.MEDIVISION Sterility RDTL, Guwahati NV (INFUSION HEALTHCARE, 84/4 SET - NV) Span Industrial complex. Second Floor, Phase-1, "F" Road, Opp. Kotak Mahindra Bank, G.I. D.C. Vatva, Ahmedabad- 382445, Gujarat 31. Compound 03BF2472 04/2024 03/2027 M/s.Paschim Banga Sterility and RDTL, Guwahati Sodium Lactate Pharmaceutical,, NH- Particulate Injection I.P. (RL) 31,TIN Mile Hat, Contamination Sonapur Hat, PSChopra, Dist. Uttar Dinajpur, PIN- 733214 (WB) 32. Compound 03BF2474 04/2024 03/2027 M/s.PASCHIM BANGA Sterility RDTL, Guwahati Sodium Lactate PHARMACEUTICAL (A Injection I.P. 500 Unit Of FARISTA ml (Ringers VANIJYA PVT. LTD.), Lactate I.P.) (RL) NH-31, TIN MILE HAT, SONAPUR HAT, P.S. CHOPRA, DIST: UTTAR DINAJPUR, PIN 733 214 (W.B.) 33. Calcium with 470823 08/2023 07/2025 M/s.Uniplus Biotech (P) Dissolution RDTL, Guwahati Vitamin D3 Ltd., 4 km. Meerut (calcium) and Tablets (CITCAL Road, Assoda 245101 Assay of Vitamin TABLETS) D3 34. Calcium 500 mg LMT240346 03/2024 02/2026 M/s.Life Max Cancer Assay of Vitamin RDTL, Guwahati with Vitamin D3 Laboratories, Plot No. D3 and 250 IU Tablets IP 106 & 106 A, Sector6A, Dissolution for IIE, SIDCUL, Haridwar- calcium249403 (U.K) 35. Co- trimoxazole PT30119 05/2023 04/2025 M/s.Omega Pharma., Dissolution RDTL, Guwahati Tablets I.P. Khasra No. 482, Village (Trimethoprim (D.S.=Double - Saliyar, Roorkee - and Strength) 247667. Distt-Haridwar Sulphamethoxazo (Uttarakhand) le) 36. PRIMAQUINE T-1338 07/2023 06/2025 M/s.Jackson Dissolution and RDTL, Guwahati PHOSPHATE Laboratories Pvt.Ltd, Assay TABLETS IP 2.5 22-24, Majitha Road, mg Bye Pass, Amritsar-143 001(India) 37. PANTOPRAZOL GT24502A 06/2024 05/2027 M/s. Hetero Healthcare Dissolution of RDTL, Guwahati E GASTRO- limited, AIIDC Industrial Buffer Stage RESISTANT Growth Centre, TABLETS IP Changsari, Niz 40mg (PANTIN) Sindurighopa (Village), Sila Sindurighopa (Mouza), Kamrup (Dist) Assam-781101 38. Albendazole MT-24G01 07/2024 06/2026 M/s.MARTIN & Dissolution RDTL, Guwahati Tablets I.P. BROWN BIOSCIENCES PVT. LTD., K.No. 918/419, Malkumajra, Nalagarh Road, Baddi, Dist. Solan (H.P.)-173205 39. Calcium & CDD23089 11/2023 10/2025 M/s. Danish Healthcare Assay of Vitamin RDTL, Guwahati Vitamin D3 (P) Ltd, 76/27-28, D3 Tablets IP Industrial Estate, Maxi (CALCI-D) Road, Ujjain-456 010 INDIA 40. Alprazolam BT1224 01/2024 12/2025 M/s.Brilliant Life The Sample does CDTL, Chennai Tablets IP 0.5 mg Sciences Pvt.Ltd. , At not conform to IP Chuval Tagarwa, Teh Standards with Detroj Dist. respect to Test Ahmedabad(Gujarat) for Dissolution only 41. Valsartan Tablets VSR1-05 04/2024 03/2026 M/s. Lark Laboratories The Sample does CDTL, Chennai IP 80mg(Valsalar- (I) Ltd., At, SP-1192 E, not conform to IP 80 Tablets) RIICO Indl Area, Phase Standards withIV, Bhiwadi-Rajasthan respect to Test for Dissolution only 42. Nutrisacc Bolus MVNUR2403 02/2024 02/2026 M/s. Maven iLab Disintegration test RDTL, Chandigarh Pvt.Ltd., No.19 and Assay of Byraveshwara Iron, Magnesium, Industrial Area, Calcium, Vitamin Andrahalli Main Road B3,Zinc and Hegganahalli, Vitamin A Bangalore-560091 43. Duloxetine T26904 01/2024 12/2025 M/s Quest Laboratories Description and RDTL, Chandigarh Gastro-resistant Limited, Plot No. 45, Dissolution Tablets IP 20 mg Sector-III, Pithampur, Dist.Dhar-454775 (M.P.) 44. Bortezomib L24BZ08A7 08/2024 07/2026 M/s. MEDION Assay of RDTL, Chandigarh Injection IP BIOTECH PVT.LTD., Bortezomib (BORTEWIN 2 Village-Kaundi, Baddi, mg Injection) Solan, Himachal Pradesh, 173205 45. Rabeprazole T- 1047 06/2023 05/2025 M/s.Jackson "Dissolution (Acid CDTL, Mumbai Gastro-resistant Laboratories Pvt. Ltd., stage) & (Buffer Tablets IP 20 mg 22-24, Majitha Road, stage) and (Robijick - 20) Bye Pass, Amritsar - Description" 143 001 (India). 46. Ramipril & AOT23322 06/2023 05/2025 M/s.ASTONEA LABS "Assay of CDTL, Mumbai Metoprolol PVT. LTD., Vill. Haripur Ramipril" Succinate Tablets Teh. Ranipur Rani, (Ramigan -MT Distt. Panchkula, 2.5/ 25 Tablets) Haryana, India - 134204 47. Sertraline SER240002B 05/2024 04/2025 M/s.Exemep "Related CDTL, Mumbai Hydrochloride FP Pharmaceuticals., substances" (USP/ EP) Block No. 628 (A & B), ECP Canal Road, Village : Luna, Tal : Padra, Vadodara 391440, INDIA 48. Pantoprazole UC-23001C 07/2023 06/2025 M/s.Ultra Drugs Pvt. "Dissolution of CDTL, Mumbai Gastro-resistant Ltd., (Unit- II) HS No. Domperidone"and Domperidone 211, K. No. 77/1, 78/1 Prolonged- Vill. Katha, Baddi, Distt. release Capsules Solan (H.P.) IP (Unipraz - DSR) 49. Paracetamol S404115 04/2024 03/2026 M/s.ION Healthcare "Related CDTL, Mumbai Paediatric Oral Pvt. Ltd., Baddi- substances" Suspension IP Barotiwala Road, (MYPAR) Baddi, Distt. Solan (H.P.)- 173 205. 50. Hydroxychloroqui HCQ19K23 11/2023 10/2026 M/s. Bajaj Healthcare "Related CDTL, Mumbai ne Sulphate Ltd., R.S. No. 1818, substances" Tableta IP 200 Manjusar - Savli Road, mg (QUEENJAJ At & Post - Manjusar, 200) Tal. Savli, Dist. Vadodra - 391775, Gujarat, India. 51. DOXYCYCLINE HDXA08 06/2023 05/2025 M/s.Hindustan "Uniformity of CDTL, Mumbai CAPSULES IP Antibiotics Ltd., At 11 weight" 100 mg W.E.A., Faridabad- 121001. Not of Standard Quality (NSQ) drugs: The drugs that fail to meet the quality standards or specifications are known as Not of Standard Quality (NSQ) drugs. (Further, the term ‘standards of quality’ is defined under the Section 16 (1) (a) of Drugs & Cosmetics Act, 1940, that the ‘standards of quality’ mean that the drug complies with the standards set out in the Second Schedule of the said Act.)

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