Home India Ministry of Health and Family Welfare State Drug Alert for the Month of September 2024...
Date: 2024-10-24 Category: Not Applicable State: Union Government Country: India

State Drug Alert for the Month of September 2024

Issued by Ministry of Health and Family Welfare · Central Drugs Standard Control Organization

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Executive Summary & Key Takeaways

What it means

  • This gazette notification is a 'Not of Standard Quality (NSQ) Alert' for drugs and pharmaceuticals for the month of September 2024, issued by State Laboratories.
  • It identifies specific drugs and pharmaceutical products that failed quality tests conducted by various Drug Testing Laboratories across India.
  • The notification lists the name of the drug, batch number, manufacturing and expiry dates, manufacturer, NSQ result, and the reporting CDSCO laboratory.
  • The products listed do not conform to the standards and specifications prescribed by the Indian Pharmacopoeia (IP) or other applicable standards.

Key Changes

  • A total of 18 drugs/products are declared as Not of Standard Quality (NSQ).
  • The NSQ results include failures in tests such as Dissolution, Assay, Disintegration, Uniformity of Dispersion, Sterility, Uniformity of Volume, Total Ash, and Descriptive part of the product.
  • Several products failed due to not conforming to IP standards or failing to meet the limits specified in Schedule V of the Drugs & Cosmetics Act & Rules.
  • Multiple products manufactured by Nestor Pharmaceuticals Ltd, Himalaya Meditek pvt.Ltd, Kerala Medical Services Corporation Ltd are listed as NSQ.
  • State Drugs Licensing Authorities of Andhra Pradesh, Arunachal Pradesh, Assam, Bihar, Chhattisgarh,Goa,Gujarat, Haryana, Himachal Pradesh, Manipur, Rajasthan, Meghalaya, Mizoram, Nagaland, Odisha, Punjab, Sikkim, Tamil Nadu, Pondicherry,Telangana,Delhi,Uttarakhand, West Bengal, Andaman & Nicobar, Dadar and Nagar Haveli; Daman and Diu, Lakshadweep have not submitted any data in respect of the Not of Standard Quality (NSQ) Alert for the Month of August, 2024 as per DCG(I) Circular dated 09.02.2024.
  • NSQ data was not received as per Format & in EXCEL SHEET from State Drugs Licensing Authorities of Karnataka (PDF format), Thiruvanthapuram (Excel format), and Jammu Kashmir (Excel Format) for the Month of August, 2024 as per DCG(I) Circular dated 09.02.2024.

Impact Analysis

Kerala Medical Services Corporation Ltd

  • Multiple products supplied by Kerala Medical Services Corporation Ltd are listed as NSQ.

Manufacturers

  • Action Item: Review manufacturing processes, quality control procedures, and supply chain to identify and rectify the root causes of the quality failures. Implement corrective and preventive actions (CAPA).

Consumers/Patients

  • Action Item: Healthcare providers should be informed about the NSQ drugs and advised to monitor patients who may have been administered these drugs. Issue public advisories to inform consumers about the affected products and potential risks.

Government/Regulators

  • Action Item: Conduct thorough investigations into the causes of the quality failures. Strengthen post-market surveillance and testing programs. Ensure timely and accurate reporting of NSQ data by State Drugs Licensing Authorities as per DCG(I) Circular dated 09.02.2024.

Hospitals and Healthcare Providers

  • Action Item: Implement robust drug procurement and quality assurance procedures. Train healthcare staff to identify and report suspected NSQ drugs.

Key Entities Referenced

CDSCO: Central Drugs Standard Control Organisation, the national regulatory authority for pharmaceuticals and medical devices in India. State Drugs Licensing Authorities: State-level regulatory bodies responsible for licensing and monitoring pharmaceutical manufacturers and distributors within their respective states. Indian Pharmacopoeia (IP): The official book of standards for drugs manufactured and marketed in India. Drugs and Cosmetics Act & Rules: The primary legislation governing the regulation of drugs and cosmetics in India. Schedule V of Drugs & Cosmetics Act & Rules: Specifies standards for patent or proprietary medicines. DCG(I) Circular dated 09.02.2024: Circular issued by Drugs Controller General of India regarding submission of NSQ data.
Official Source Record View Original Source →
See Full Document Text
NOT OF STANDARD QUALITY ALERT FOR THE MONTH OF SEPTEMBER– 2024. B. State Laboratories S.No Product/Drug Batch No. Manufacturing Expiry Manufactured By NSQ Result Reported by Name Date Date CDSCO Laboratory 1. Neurotem-NT CPT-2698 Mar-24 Feb-26 Catasta Pharmaceuticals The given Drug Drug Testing Laboratory Plot No. 113, DIC, Sample does Srinagar (J&K) vide Industrial Area, Baddi Distt. not comply to report on Form 13 Solan (H.P) the contents of bearing No. L/DA/2024- Mrk. By : Cosway Assay with 25/1191 Biosciences Coprporate respect to Dated: 05.09.2024. Office : Khasra No. Pregabalin ( (Report attached as 2054/1724, 1725 SCO No. 23.26% of Annexure A) 11 Baddi Barotiwala Road claim) The. Baddi Distt. Solan H.P 173205 2. Cefuroxime Axetil JAK-23 Jul-23 Jun-25 Agron Remedies Pvt Ltd The sample Combined Food & Drug Tablets IP 500 mg Sarverkhera Moradabad fails in the Testing Laboratory (JKMSCL Supply) Road Kashipur 244 713 Description, Jammu (J&K) vide (Uttarakhand) Dissolution and report on Form 13 Assay of bearing No. Cefuroxime CFDL/J/2024-25/1120 Axetil w.r.t the Dated: 26.09.2024. sample portion (Report attached as received as Annexure B) above 3. Loperamide T-16201 May-24 Apr-26 Karnani Pharmaceuticals The sample Drug Testing Hydrochloride Pvt. Ltd , 38 Pharma City , does not Laboratory Srinagar Tablets IP Selaqui Dehradun -248011 conform to IP (J&K) vide report on (JKMSCL Hospital with respect to Form 13 bearing No. Supply) the test for L/DA/2024-25/1311 Dissolution & Dated: 27.09.2024. Assay (Report attached as Annexure C)4. Floxages-OZ SPY41223 12/23 11/26 Suraksha Pharma pvt.Ltd, It fails the test Drugs Testing (Ofloxacin and 410, Karondi, Roorkee-247 ‘Dissolution’ as Laboratory Ornidazole Tablets 667, Uttarakhand per IP Thiruvananthapuram IP) 5. Wintel 40 Tablets H T N257D 04/24 03/26 Himalaya Meditek pvt.Ltd, It fails the test Drugs Testing Plot No. 35 & 36, ‘Dissolution’ as Laboratory Pharmacity, Selaqui, per IP Thiruvananthapuram Industrial Area, Dehradun - 248 197 6. Moxica -250 SD 243 08/23 07/25 Indica Pharmaceuticals (P) It fails the test Drugs Testing [Amoxicillin Ltd, Bapunagar, ‘Disintegration’ Laboratory Dispersible Tablets Ahmedabad- 382 345 and ‘Uniformity Thiruvananthapuram IP 250 mg] of Dispersion’ specified in the Laboratory Protocol as per IP 7. Frusemide Injection FRIB-03 01/24 12/25 Nestor Pharmaceuticals It fails the test Drugs Testing IP 20 mg Ltd, 11, Western Extension ‘Sterility’ as per Laboratory Area, Faridabad -121001 IP Thiruvananthapuram 8. Cloxacillin Sodium CLCA-04 04/23 03/25 Nestor Pharmaceuticals The sample Drugs Testing Capsules IP 250 Ltd, 11, Western Extension does not Laboratory mg Area, Faridabad -121001 conform to IP Thiruvananthapuram Standards with respect to ‘Descriptive part’ of hard gelatin capsules and further tests cannot be performed due to reasons secified in the laboratory protocol 9. Fluorometholone CHE-3044 05/23 04/25 Cotec Healthcare pvt.Ltd, It fails the test Drugs Testing Eye Drops IP K.H.No.593/1, Roorkee, ‘Uniformity of Laboratory Dehradun Highway, Volume’ and ThiruvananthapuramKishanpur, Roorkee- 247 ‘Assay’ as per 667, UK IP 10. Panlib 40 Tablets H T N 102A 01/24 12/25 Himalaya Meditek pvt.Ltd, It fails the test Drugs Testing Plot No. 35 & 36, Dissolution’ and Laboratory Pharmacity, Selaqui, ‘Assay’ as per Thiruvananthapuram Industrial Area, Dehradun IP 11. B - Cidal 625 U T232859 03/24 08/25 VADSP Pharmaceuticals, The content of Drugs Testing Plot No. 124, EPIP Clavulanic acid Laboratory Indl.Area, Phase 1, is not with in the Thiruvananthapuram Jharmajri, Baddi (HP)- limit of 174103 ‘Schedule V’ of Drugs and Cosmetics Act & Rules thereunder 12. Trypsin, Bromelain TTF24065 06/24 11/25 Tiruvision Medcare, Plot The sample fails Drugs Testing & Rutoside No. 177, HPSIDC, the test Laboratory Trihydrate Tablets Indl.Area, Baddi, Dist Solan ‘Disintegration’ Thiruvananthapuram [Flavoshine] HP 173 205 specified in the Laboratory protocol as per IP 13. C Mont LC Kid 60 AL 23206 11/23 10/25 Cian Healthcare Ltd, kh The content of Drugs Testing ml (Montelukast & No.248, Village sisonia, montelukast is Laboratory Leveocetirizine Bhagwanpur, Roorkee, not within the Thiruvananthapuram Dihydrochloride Haridwar, Uttarakhand- 247 limits of syrup) 661 Schedule ‘V’ of Drugs & Cosmetics Act & Rules 14. Yogaraja Guggulu P 592324 10/23 09/26 Oushadhi, The The sample Drugs Testing Tablet Pharmaceutical corporation does not Laboratory (IM) , Kerala Ltd, conform to API Thiruvananthapuram Kuttanellur, Thrissur- 68 Standards. It 0014 fails the tests ‘Total Ash’ as per API Standards.15. Telmisartan Tab IP D1153/24-25 Kerala Medical Services The sample Drugs Testing 40 mg Corporation Ltd, Thycaud does not Laboratory P.O, Thiruvananthapuram- conform to IP Thiruvananthapuram 14 Standards with respective to ‘Descriptive part’ of tablets and further tests cannot be performed due to above reasons. 16. Pantoprazole Inj.BP D 0923/24- Kerala Medical Services It fails the test Drugs Testing 40 mg 25 Corporation Ltd, Thycaud ‘Sterility’ Laboratory P.O, Thiruvananthapuram- specified in the Thiruvananthapuram 14 laboratory protocol as per IP 17. Glimepiride Tab IP D 1 272/24-25 Kerala Medical Services The sample fails Drugs Testing Corporation Ltd, Thycaud the descriptive Laboratory P.O, Thiruvananthapuram- part for tablets Thiruvananthapuram 14 as they are not sufficiently hard to withstand handling without crumbling or breaking and further tests cannot be performed due to above reason 18. Cough Syrup D 1278/24- Kerala Medical Services The sample fails Drugs Testing 25 Corporation Ltd, Thycaud the ‘Descriptive Laboratory P.O, Thiruvananthapuram- part’ for oral Thiruvananthapuram 14 dosage forms of Schedule V of drugs and cosmetics Act and Rules, asthe syrup contains red coloured suspended paticles NOTE: 1. NSQ data was not received as per Format & in EXCEL SHEET from State Drugs Licensing Authorities of Karnataka (PDF format), Thiruvanthapuram (Excel format), and Jammu Kashmir (Excel Format) for the Month of August, 2024 as per DCG(I) Circular dated 09.02.2024. 2. State Drugs Licensing Authorities of Andhra Pradesh, Arunachal Pradesh, Assam, Bihar, Chhattisgarh,Goa,Gujarat, Haryana, Himachal Pradesh, Manipur, Rajasthan, Meghalaya, Mizoram, Nagaland, Odisha, Punjab, Sikkim, Tamil Nadu, Pondicherry,Telangana,Delhi,Uttarakhand, West Bengal, Andaman & Nicobar, Dadar and Nagar Haveli; Daman and Diu, Lakshadweep have not submitted any data in respect of the Not of Standard Quality (NSQ) Alert for the Month of August, 2024 as per DCG(I) Circular dated 09.02.2024.

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